Journal: International Journal of Pharmaceutics: X
Article Title: Taste-masked tilmicosin-loaded nanostructured lipid carriers at pilot scale for improved bioavailability and enhanced efficacy against Salmonella infection in swine
doi: 10.1016/j.ijpx.2026.100560
Figure Lengend Snippet: Pharmacodynamic evaluation of TMS@NLCs in Salmonella -infected piglets. (A) Infection and treatment timeline. Bacterial loads in liver (B), spleen (C) and colon (D). Concentration of IL-1β (E) and IL-6 (F) in serum. mRNA expression of Claudin-1 (G) and Occludin (H) in colon. (I) Intestinal immunohistochemical for Occludin. Scale bar: 100 μm. (J) Representative histopathology of liver and colon. Scale bar, 200 μm. Black arrows: inflammatory cell infiltration; yellow arrows: erythrocytes. ⁎ P < 0.05 , ⁎⁎ P < 0.01; # P < 0.05 , ## P < 0.01. Abbreviations: Sal. ( Salmonella typhimurium SL1344), C-TMS (commercial TMS solution). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Article Snippet: Occludin monoclonal antibody was obtained from Abmart Co., Ltd. (Shanghai, China).
Techniques: Infection, Concentration Assay, Expressing, Immunohistochemical staining, Histopathology